GLP-1 weight loss pills under development
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Researchers believe they may have the next better version of Ozempic in their work.
At Tufts University, scientists have developed a new drug that aims to Increase weight loss It can also reduce nausea, muscle loss and weight associated with the popular GLP-1 drug.
The goal is “Four times action” drug According to a study press release, in order to achieve long-lasting weight loss of 30% – matching the effectiveness of bariatric surgery, this can reduce the size of the stomach.
Can GLP-1 weight loss pills like Ozempic become “everything drugs”?
How drugs are different
Semaglutide drugs (e.g. Ozempic and Wegovy) mimic the natural hormone GLP −1 (inspiron-like peptide 1), while tirzepatides (e.g. Mounjaro and Zepbound) target GLP-1 receptors and GIP receptors (GIP) and GIP (glycemic-dependent sugar-dependent sugar-dependent insulin trypsin receptor receptor receptors).
Scientists have developed a new drug that aims to increase weight loss while reducing nausea, muscle loss and weight associated with the popular GLP-1 drug. (iStock)
Tufts’ new drug targets four hormones – GLP-1, GIP, glucagon (insulin correspondence) and peptide YY, which can reduce hunger and slow stomach emptying, which may Promote fat burning.
“We built a single experimental peptide that works like four hormones at a time, so we won’t be too hard,” Dr. Tristan Dinsmore, a researcher at Tufts University, told Fox News Digital.
“Instead, we push four ‘dimming switches’ together to manage appetite, blood sugar and energy use.”
Dinsmore said that because GLP ‑1 and PYY can cause nausea at higher doses, researchers rely on GIP (known to relieve nausea to balance things,” Dinsmore said.
“We built a single experimental peptide that works like four hormones at a time, so we don’t try too hard to press a button.”
He continued: “Besides helping with plumping and glucose control, GIP signaling has an anti-Nausea effect – it can even prevent nausea in preclinical models, which is why we prioritize it.”
“By adding PYY to the GLP ‑ 1/GIP/Glucagon Trio, we hope to rely less on GLP ‑ 1 and glucagon to drive weight loss, thus reducing the chance of nausea (from GLP ‑ 1/PYY) and Hyperglycemia Danger (from glucagon) while maintaining benefits. ”
One researcher said that because GLP ‑1 and PYY can cause nausea at higher doses, the researchers rely on GIP (known to relieve nausea and balance things up). (iStock)
The drug is still in the experimental/preclinical stage and has not been tested in human trials.
The development of the drug is published in the Journal of the American Chemical Society.
Doctor’s reaction
Dr. Brett Osborn, Florida neurosurgeon and Lifespan expertis a strong advocate of GLP-1 drugs.
“We have a lot of highly effective GLP-1 agonists in front of us.”
“For most people, a single AGENT GLP-1 like Ozempic Works.” Osborne, who was not involved in the Tufts study, told Fox News Digital. “when Experienced physician Supervise you. ”
“We don’t need more medication to treat more and more chronic problems,” he added. “We have a lot of highly effective GLP-1 agonists in front of us.”
Obesity is estimated to affect more than 40% of American adults and is associated with dozens of diseases including type 2 diabetes, heart disease, stroke, sleep apnea, high blood pressure and several types of cancer. (iStock)
He said the biggest risk of GLP-1 is muscle loss and malnutrition of ingredients. To prevent this, doctors stress the need for proper daily protein and consistent strength training.
Treat “chronic” Obesity DiseasesOsborn recommends micronization or intermittent doses of GLP-1 for nutrition, sexual resistance training, hydration and sleep.
Mediterranean diet pairs with other lifestyle changes slashes diabetes risk
“Essentially, use effective drugs and combine them together Discipline habits,” he advised. “I have used this method over the years, and many of my patients have also been very good forgiving for a long time. ”
Sue Decotiis, MD, MD, a medical weight loss doctor in New York City, notes Control appetiteenhancing metabolism and increasing fat burning (although also balancing the interaction between blood sugar and insulin) is a “complex function”.
“Even if new mechanisms of weight loss medication are added, individual patients will have multiple responses to fat mass,” one expert said. (iStock)
“Other mechanisms provided by new drugs may help some people, but not necessarily most lose weight The patient, “Decotiis, who was not involved in the study, also told Fox News Digital.
“Even with the addition of new mechanisms of weight loss medication, individual patients will have multiple responses to fat mass.”
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She noted that patients taking GLP-1 usually do not experience muscle and bone loss.
“Good care Medical weight loss She said.
Limitations and future research
The researchers acknowledge that new drugs have some limitations.
“Other mechanisms provided by the new drug may help some people, but not necessarily most people with weight loss.”
“This is a design study that demonstrates the potential of next generations and even tailor-made drugs,” Dinsmore told Fox News Digital. “Our data are from cell-based assays, not from animals or humans (not yet).
“Choose the safest and most effective balance of the four pathways will require Living research, and Clinical trials. ”
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Dinsmore recommends that people using GLP-1-based drugs should adhere to their clinician’s guidance.
“This is not the medicine you can buy today,” he said of the new drug. “Our work is the next generation concept, aiming to improve results and Reduce nausea By spreading the work into four hormones, rather than overloading one. ”
It is estimated that obesity affects more than 40% of American adults and is associated with dozens of diseases including type 2 diabetes, heart disease, stroke, sleep apnea, hypertension and several types of cancer.
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“What drives us is that we can design a drug to treat obesity and alleviate a long list of risks Health issues Trouble society.
